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Prognosis of gamma-glutamylcysteine synthetase deficiency, gamma-glutamyl transpeptidase deficiency, 5-oxoprolinase deficiency and dipeptidase deficiency is unclear and difficult to predict as very few patients have been reported worldwide

In fact, there are entire research funds dedicated to analyzing the makeup of healthy and diseased individuals (2)

Bad lifestyles such as prolonged heavy drinking, coffee consumption or smoking can lead to elevated Hcy level by reducing intake or increasing consumption of B vitamins and FA

(74) found that NOR had a pro-apoptotic effect on FLSs of AIA rats, and its molecular mechanism was achieved by promoting the release of cytochrome C, regulating the Bax/Bcl-2 expression-mediated mitochondrial dependent pathway, and up-regulating the p53 pathway

By incorporating miRNA structures into gene therapy agents, it aims to inhibit the production of the mutant Z-AAT protein and promote the production of functional A1AT (79)